Manuscript accepted in Journal of the Association for Research in Otolaryngology (JARO)

The paper titled "Genome-Wide Association Study of Age-Related Hearing Loss in CFW Mice Identifies Multiple Genes and Loci, Including Prkag2" was published in the Journal of the Association for Research in Otolaryngology (JARO) and was authored by members of the Palmer Lab in collaboration with Dr. Rick Friedman’s group.

The study, led by Dr. Oksana Polesskaya, identified multiple genetic factors associated with age-related hearing loss (ARHL) using Carworth Farms White (CFW) mice. Researchers conducted GWAS in over 900 mice and discovered ten significant loci linked to ARHL. Functional testing confirmed that disruption of Prkag2 leads to high-frequency hearing loss, implicating it as a causal gene. These findings offer promising new targets for the development of therapies to treat ARHL, a common condition affecting aging populations.

Authors: Oksana Polesskaya, Ely Boussaty, Riyan Cheng, Olivia Lamonte, Thomas Zhou, Eric Du, Thiago Missfeldt Sanches, Khai-Minh Nguyen*, Mika Okamoto*, Abraham A Palmer, Rick Friedman

(Current and past* Palmer Lab members)

Congratulations!

Journal of the Association for Research in Otolaryngology (JARO), 21 May 2025

DOI: https://doi.org/10.1007/s10162-025-00994-1

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