Manuscript accepted in Nature Communications

The manuscript titled "Novel insights into the genetic architecture and mechanisms of host/microbiome interactions from a multi-cohort analysis of outbred laboratory rats" was accepted in Nature Communications.

Authors: Helene Tonnele, Denghui Chen, Felipe Morillo, Jorge Garcia-Calleja, Apurva S Chitre, Benjamin B Johnson, Thiago Missfeldt Sanches, Marc Jan Bonder, Antonio Gonzalez, Tomasz Kosciolek, Anthony M George, Wenyan Han, Katie Holl, Aidan Horvath, Keita Ishiwari, Christopher P King, Alexander C Lamparelli, Connor D Martin, Angel Garcia Martinez, Alesa H Netzley, Jordan A Tripi, Tengfei Wang, Elena Bosch, Peter A Doris, Oliver Stegle, Hao Chen, Shelly B Flagel, Paul J Meyer, Jerry B Richards, Terry E Robinson, Leah C Solberg Woods, Oksana Polesskaya, Rob Knight, Abraham A Palmer, Amelie Baud.

(Current Palmer Lab members)

Congratulations!

Nature Communications, 2025, in press

Figure 4: Microbiome-associated loci. This porcupine plot shows the association values for all microbiome phenotypes (n = 2,294 phenotypes from 4 cohorts). The lower line (-logP = 5.8) reflects the genome-wide significance threshold for an individual trait, which accounts for the number of independent SNPs tested; the higher line (-logP = 8.4) is the adjusted significance threshold, which in addition accounts for the number of independent microbiome phenotypes examined in each cohort. The larger, colored dots highlight genome-wide significant associations for microbiome phenotypes that have an annotation at the genus level. The color of the dot refers to the genus affected. The shape of the dot refers to the cohort in which the association was identified.

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