Manuscript accepted in the American Journal of Human Genetics
The manuscript titled "Data-driven RNA phenotyping captures genetically regulated dimensions of the transcriptome" was accepted for publication in the American Journal of Human Genetics.
Authors: Daniel Munro, Alexander Gusev, Abraham A. Palmer, and Pejman Mohammadi
(Current Palmer Lab members)
Congratulations!
American Journal of Human Genetics, 2026, in press*
DOI: https://doi.org/10.1016/j.ajhg.2026.06.005
(a) Diagram of the LaDDR procedure. (b) Example of DDPs for one gene, ZNF844. Top: The three annotated isoforms of ZNF844 are shown, and, as in the two panels below, the x-axis represents the coverage bin index along the gene and is not proportional to genomic position, since actual bin widths vary. Isoforms are shown here for reference and are not used by LaDDR. Middle: RNA-seq coverage distribution (median and interquartile range) at each bin across all tibial nerve samples. Bottom: DDPs were generated using LaDDR. Tibial nerve samples were grouped into 10 equal-sized deciles based on their values for two resulting ZNF884 phenotypes, DDP1 and DDP2, and median coverage at each bin is shown for each decile. Coverage in all three panels was scaled per sample to adjust for sequencing depth. (c) TWAS association for DDP2 in b. Top: Nominal p-values for each variant in the +/- 500 kb cis-window from xQTL mapping of ZNF844 DDP2 in tibial nerve are shown. The location of ZNF844 is shown above for reference and its transcription start site is indicated in the plots with a vertical line. Bottom: GWAS p-values for standing height (UK Biobank) in the same window.
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