It is of interest to know the locations and causes of HS rat genotype gaps. For example, little can be done to address a gap due to a lack of founder variation, but a gap due to poor genotyping may be amenable to improved genotyping methods. This project set out to discover gap locations in the context of minor allele frequency (MAF), both in founders and the modern population.
Ties are a problem for rank-based normalization. All samples must be assigned distinct ranks. Therefore, all ties must be broken in some way. Tie-breaking methods include the order samples appear, the alphanumerical order of sample identifiers, or randomly by a pre-determined seed number. We seek to determine the extent to which particular tie-break choices affect the GWAS results.
The manuscript titled ”Genome-wide association study of delay discounting in Heterogenous Stock rats” was accepted in Genes, Brain and Behavior.
Authors include current Palmer Lab members: Montana Lara, Apurva Chitre, Denghui Chen, Benjamin Johnson, Khai-Minh Nguyen, Sakina Muckadam, Thiago Sanches, Oksana Polesskaya, and Abraham Palmer.
Nina joined the Palmer Lab in July 2024 as a laboratory/animal assistant.
She graduated from UC Santa Barbara with a bachelor of science degree in Microbiology, and she plans to pursue graduate school.
Welcome, Nina!
Michael Rempel joined the Palmer Lab in July 2024 for a five-week internship on the Wet Lab team. His work focuses on genotyping Cadm2 transgenic rats which were created as an animal model to study the effect of mutations on the recursive splice site in Cadm2, which is known to be strongly associated with ADHD in humans.
Michael is a high school student at SET High. He is interested in modern biotechnology, including computational biology. Outside of school, Michael spends time with friends, volunteers at concerts, and helps with native habitat restoration in Rose Canyon.
Welcome, Michael!
The manuscript titled ”Rare and Common Variants Associated with Alcohol Consumption Identify a Conserved Molecular Network” was accepted in Alcohol, Clinical and Experimental Research.
Authors include current Palmer Lab members: Brittany Leger and Abraham A Palmer.
The manuscript titled “A multi-symptomatic model of heroin use disorder in rats reveals distinct behavioral profiles and neuronal correlates of heroin vulnerability versus resiliency” was accepted in the American Journal of Psychiatry.
Update: title changed to “Distinct Behavioral Profiles and Neuronal Correlates of Heroin Vulnerability Versus Resiliency in a Multi-Symptomatic Model of Heroin Use Disorder in Rats.”
DOI: https://doi.org/10.1176/appi.ajp.20230623
Dr. Palmer hosted and presented a talk at a summit for fellow Glo1 researchers at UC San Diego on April 19, 2024. The summit was an occasion for researchers who are working on Glyoxalase 1 (Glo1) to meet and hear about one another’s projects.
Palmer Lab member and UC San Diego Biomedical Sciences graduate student Brittany Leger presented a research poster at the 19th Annual Lewis L. Judd Young Investigators Research Symposium on April 25, 2024.
Dr. Palmer was invited to give a talk for Loma Linda University’s Center for Genomics seminar series, titled “Using genetics to understand addiction,” held on campus at Loma Linda on April 18, 2024.
He was hosted by Dr. Charles Wang, MD, PhD, MPH, the founding director of the Center.
