The article, “Analysis of independent cohorts of outbred CFW mice reveals novel loci for behavioral and physiological traits and identifies factors determining reproducibility“, has been accepted for publication in G3. This study identifies the factors that impact reproducibility of GWAS studies in mice and demonstrates methods to obtain robust results from mapping complex traits in GWAS studies.
Congrats!
Elizabeth Alcantara joined the Palmer Lab in December of 2020 as an undergraduate volunteer and recently graduated from UCSD with a B.S in Neurobiology. She has recently been admitted to the UCSD BS/MS program and is now a Graduate Student Researcher in the lab. She will be focusing her work on investigating the relationship between Glo1 and drug addiction. In her free time, she enjoys eating out and trying new foods, reading, binge watching shows, and playing with her two cats.
Welcome, Liz!
Han Chen Joined the Palmer lab in September of 2021, he recently graduated from UC Santa Cruz with a B.S in Bioinformatics. His hobbies are playing tennis, cooking, and drawing.
Welcome, Han!
The manuscript , “Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry”, has been provisionally accepted for publication in Molecular Psychiatry. Dr. Sandra Sanchez-Roige is the first author and Dr. Abraham Palmer is the last author; they are also co-corresponding authors. In addition, Mariela Jennings, Sevim Bianchi, and Yuye Huang, who are members of Dr. Sanchez-Roige’s lab, are co-authors. This study identified two genome wide significant loci associated with problematic opioid use (POU). Additional genetic correlations along with POU were found including alcohol dependence,
The 2021 Complex Trait Consortium (CTC) meeting was held virtually from Manchester, UK from September 1-3, 2021.
Abraham Palmer, Oksana Polesskaya, Daniel Munro, Brittany Leger, Milad Mortazavi, Apurva Chitre, Joel Leal-Gutierrez, and Denghui Chen has attended.
Dr. Abraham Palmer has received a $200,000 supplement for the project titled, “Making data from the center for GWAS in out bred rats FAIR and AI/ML ready”. NIDA has provided these funds to improve the AI/ML (Artificial Intelligence/Machine Learning)-readiness of data from the Center for GWAS outbred rats. Additionally, these funds will be used to address important shortcomings in the processing of several large datasets and be used to implement new methods of effective information sharing.
The recently published article, “Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction“, has been fully published on Nature Neuroscience. This study integrates a multivariate approach which uses summary statistics from GWAS data to identify genetic variants associated to externalizing phenotypes. UCSD Health has highlighted this study in its recent press release.
Dr. Palmer is a co-investigator on an NIH/HIDCD grant received by Dr. Rick Friendman, entitled “The genetics of functional decline in the aging vestibular system: A GWAS and gene expression analysis in aging mice and humans.” This project seeks to identify and study the genetic basis of age-related hearing impairment.
Clara Ortez joined the Palmer Lab in August of 2021, she recently graduated from UC San Diego with a B.S. in Cognitive Science specialization Neuroscience, during which she interned at the George Lab studying behavioral components of drug use. She’s from the Bay Area but loves San Diego weather and beaches, where you can find her reading a good book!
This program provides a rich training environment which includes several activities allowing for interaction among faculty and other students. Furthermore, fiscal support is provided from their NIGMS training grant.
Congrats, Brittany!
